PO-0791 Neoadjuvant treatment potentially improves outcome in resectable pancreatic cancer: metaanalysis
نویسندگان
چکیده
منابع مشابه
Neoadjuvant therapy for resectable pancreatic cancer
The use of neoadjuvant therapies has played a major role for borderline resectable and locally advanced pancreatic cancers (PCs). For this group of patients, preoperative chemotherapy or chemoradiation has increased the likelihood of surgery with negative resection margins and overall survival. On the other hand, for patients with resectable PC, the main rationale for neoadjuvant therapy is tha...
متن کاملSurvival outcome and prognostic factors of neoadjuvant treatment followed by resection for borderline resectable pancreatic cancer
Purpose Neoadjuvant treatment may provide improved survival outcomes for patients with borderline resectable pancreatic cancer (BRPC). The purpose of this study is to evaluate the clinical outcomes of neoadjuvant treatment and to identify prognostic factors. Methods Forty patients who met the National Comprehensive Cancer Network definition of BRPC and received neoadjuvant treatment followed ...
متن کاملNeoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer
The majority of patients with localized pancreatic cancer (PC) who undergo surgery followed by adjuvant therapy will develop metastatic disease, suggesting that surgery alone is not sufficient for cure and micrometastases are present even when are not clinically detected. As such, the delivery of early systemic therapy may be a rational alternative to a surgery-first approach, in an effort to p...
متن کاملNeoadjuvant therapy in resectable pancreatic cancer: a critical review.
BACKGROUND Pancreatic cancer is among the deadliest tumors. Due to intrinsic chemo- and radio-resistance, surgical resection remains the only chance for cure. However surgery alone is unable to considerably improve survival and complementary chemotherapy and radiotherapy in a multimodal approach have been tested. Adjuvant chemotherapy yielded a modest outcome improvement, whereas the use of adj...
متن کاملClinical impact of neoadjuvant treatment in resectable pancreatic cancer: a systematic review and meta-analysis protocol
INTRODUCTION Although the only curative strategy for pancreatic cancer is surgical resection, up to 85% of patients relapse after surgery. The efficacy of neoadjuvant treatment in resectable pancreatic cancer (RPC) remains unclear and there is no systematic review focusing fully on this issue. Recently, two prospective trials of neoadjuvant treatment in RPC were terminated early because of slow...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2019
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(19)31211-3